T16Ainh-A01 showed a marked inhibitory effect on the mRNA levels of ANO1 and α-SMA, but had a negligible effect on ANO1 at the protein level. T16Ainh-A01 and CaCCinh-A01 led to the significant repression of cell proliferation, cell migration, and collagen secretion in CFs.

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells.

New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit? Br. J. Pharmacol. 172(16),. 4158 Objective: Primary cultured cochlear stria vascularis endothelial cells (ECs) of guinea pig were used to investigate the expression changes of TMEM16A and its 26 Feb 2020 In perforated current-clamping method, the application of T16Ainh-A01 and reduction of. Cl− extended excitation periods in rod bipolar cells, niflumic acid, open state channel block, TMEM16A, T16AInh-A01, voltage- dependence; *Correspondence to: Normand Leblanc; Email: NLeblanc@ Medicine.

T16ainh-a01

T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01 is a potent inhibitor of transmembrane protein 16A (TMEM16A), inhibiting TMEM16A-mediated chloride currents (IC50 of ~1 µM),and functions as a calcium-activated chloride channel (CaCC). The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).

T16Ainh-A01 is a potent inhibitor of transmembrane protein 16A (TMEM16A), inhibiting TMEM16A-mediated chloride currents (IC50 of ~1 µM),and functions as a calcium-activated chloride channel (CaCC).

Cited in 8 publications. View and buy high purity T16Ainh - A01. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor.

25 Jul 2016 Our results therefore demonstrate that T16Ainh-. AO1 is acting on the calcium- dependent chloride channel in pancreatic acinar cells, and,

T16Ainh-A01 and CaCCinh-A01 led to the significant repression of cell proliferation, cell migration, and collagen secretion in CFs. T16Ainh - A01, Tocris Bioscience 10mg Chemicals:Organic Compounds:Organic nitrogen compounds:Organonitrogen compounds:N-arylamides Background and Purpose T16Ainh‐A01, CaCCinh‐A01 and MONNA are identified as selective inhibitors of the TMEM16A calcium‐activated chloride channel (CaCC). The aim of this study was to examine the c View and buy high purity T16Ainh - A01 from Tocris Bioscience. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 publications.

T16Ainh-A01 is a potent inhibitor of transmembrane protein 16A (TMEM16A), inhibiting TMEM16A-mediated chloride currents (IC50 of ~1 µM),and functions as a calcium-activated chloride channel (CaCC). In contrast, spontaneous Ca2+ waves in isolated RUICC were only partially reduced by CACCinh-A01 and T16Ainh-A01.
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Cited in 8 publications. CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). For research use only. We do not sell to patients.

Background and Purpose T16Ainh‐A01, CaCCinh‐A01 and MONNA are identified as selective inhibitors of the TMEM16A calcium‐activated chloride channel (CaCC). The aim of this study was to examine the c T16Ainh - A01, Tocris Bioscience 10mg Chemicals:Organic Compounds:Organic nitrogen compounds:Organonitrogen compounds:N-arylamides TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
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T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current.

800-343-7475; Contact Us; Cart Chemical Formula: C19H20N4O3S2 Exact Mass: 416.0977 Molecular Weight: 416.514 Elemental Analysis: C, 54.79; H, 4.84; N, 13.45; O, 11.52; S, 15.39 Synonym: T16Ainh-A01 T16Ainh A01 T16AinhA01 T16A(inh)-A01 T16A(inh) A01 T16A(inh)A01 Chemical Name: 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide InChi Key: QSIYTNYMBWYHAA … T16Ainh - A01 Catalog No.GC17930: inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) Size Price Stock Qty; 5mg $30.00. In stock 10mg In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+.